Instent restenosis (ISR) occurs when scar tissue builds up inside an artery that has been stented to the point that blood flow is decreased. Drs. Krishnaswamy, Khatri and Ellis discuss how long stents generally last, symptoms of restenosis, risk factors for restenosis, techniques used during procedures that can help prevent ISR, protocols and treatment options for in-stent restenosis, and upcoming research studies for ISR. Learn more about the Center for Complex Coronary Interventions - https://my.clevelandclinic.org/departments/heart/depts/complex-coronary-interventions Dr. Amar Krishnaswamy - https://my.clevelandclinic.org/staff/16286-amar-krishnaswamy Dr. Jay Khatri - https://my.clevelandclinic.org/staff/21654-jaikirshan-khatri Dr. Stephen Ellis - https://my.clevelandclinic.org/staff/1214-stephen-ellis