Alcohol septal ablation has been performed at Cleveland Clinic since the late 1980’s. Dr. Samir Kapadia describes optimal patients to undergo this procedure and outcomes of septal ablation vs. surgery (septal myectomy). Alcohol septal ablation is a good treatment option for appropriately selected patients. Hypertrophic Cardiomyopathy (HCM) requires a team approach involving cardiologists, surgeons and genetic counselors to plan the best procedure for each individual patient.